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ey0019.14-4 | Steroidogenesis and beyond | ESPEYB19

14.4. Quantification of androgens and their precursors in full-term human placenta

T Yoshida , K Matsumoto , M Miyado , Y Miyashiro , H Sago , R Horikawa , M Fukami

Eur J Endocrinol 2021;185:K7K11 doi: 10.1530/EJE-21-0312Brief Summary: Steroid profiling of 10 placentas of healthy full-term neonates (five male and five female) using liquid chromatography-tandem mass spectrometry revealed the presence of C11-oxy C19 steroids (androgens) in the fetal-placental unit at term pointing to alternative androgen pathways in this unit.<p cla...

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ey0020.1-3 | Antenatal and Perinatal Thyroidology | ESPEYB20

1.3. Incidence of and risk factors for neonatal hypothyroidism among women with Graves' disease treated with antithyroid drugs until delivery

A Yoshihara , JY Noh , K Inoue , N Watanabe , M Fukushita , M Matsumoto , N Suzuki , A Suzuki , A Kinoshita , R Yoshimura , A Aida , H Imai , S Hiruma , K Sugino , K Ito

Brief summary: Neonates of mothers suffering from Graves Disease during pregnancy are at risk for hyper- or hypothyroidism postnatally. The risk for hypothyroidism of neonates exposed to maternal anti-thyroid drugs until birth is unknown. This large retrospective study aimed at investigating 1) the incidence of hypothyroid neonates in a large cohort of mothers treated with anti-thyroid drugs until birth, and 2) identify a cutoff for maternal anti-thyroid drug doses assoc...

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ey0017.1-5 | Hypopituitarism: Disease Modeling and New Discoveries | ESPEYB17

1.5. Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells

T Kasai , H Suga , Sakakibara , C Ozone , R Matsumoto , M Kano , K Mitsumoto , K Ogawa , Y Kodani , H Nagasaki , N Inoshita , M Sugiyama , T Onoue , T Tsunekawa , Y Ito , H Takagi , D Hagiwara , S Iwama , M Goto , R Banno , R Takahashi , H Arima

To read the full abstract: Cell Rep. 2020 Jan 7;30(1):1824.e5. doi: 10.1016/j.celrep.2019.12.009. PMID: 31914385.The hypothalamic-pituitary axis influences many body organ systems and its dysfunction can be fatal. A proper in vitro model is important for understanding the disease mechanisms affecting pituitary function. Based on their previous anterior pituitary modelli...

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ey0016.14-4 | (1) | ESPEYB16

14.4. A reprogramming human T cell function and specificity with non-viral genome targeting

TL Roth , C Puig-Saus , R Yu , E Shifrut , J Carnevale , PJ Li , Hiatt , J Saco , P Krystofinski , H Li , V Tobin , DN Nguyen , MR Lee , AL Putnam , AL Ferris , JW Chen , JN Schickel , L Pellerin , D Carmody , G Alkorta-Aranburu , D Del Gaudio , H Matsumoto , M Morell , Y Mao , M Cho , RM Quadros , CB Gurumurthy , B Smith , M Haugwitz , SH Hughes , JS Weissman , K Schumann , JH Esensten , AP May , A Ashworth , GM Kupfer , SAW Greeley , R Bacchetta , E Meffre , MG Roncarolo , N Romberg , KC Herold , A Ribas , MD Leonetti , A Marson

To read the full abstract: Nature. 2018 Jul;559(7714):405409This article decries a CRISPR-Cas9 genome-targeting system that does not require viral vectors, allowing rapid and efficient insertion of large DNA sequences at specific sites in the genomes of primary human T cells, while preserving cell viability and function.The common approach to genetically...

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ESPE Yearbook of Paediatric Endocrinology

14.4. Quantification of androgens and their precursors in full-term human placenta

1.3. Incidence of and risk factors for neonatal hypothyroidism among women with Graves' disease treated with antithyroid drugs until delivery

1.5. Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells

14.4. A reprogramming human T cell function and specificity with non-viral genome targeting

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